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Muse Cells Uncover
New Possibilities
in the World of
Regenerative Medicine

Muse Cells Uncover
New Possibilities
in the World of
Regenerative Medicine

Muse Cells Uncover New Possibilities
in the World of
Regenerative Medicine

Muse Cells Uncover New Possibilities
in the World of
Regenerative Medicine

Muse cells and the Life Science Institute, Inc. (LSII)

LSII has been developing novel Muse cell treatments since 2015
in order to respond to unmet medical needs.

A New Hope for Regenerative Medicine:
Muse Cells

Pluripotent stem cells have recently attracted a great deal of attention in regenerative medicine, in which practical use is advancing due to their capacity to differentiate into a variety of cell types in the human body. Muse cells (Multilineage-differentiating stress enduring cells) are the latest addition to this group.

About Muse Cells

Discovered by Professor Mari Dezawa et al. at Tohoku University in 2010, Muse cells are a novel type of pluripotent stem cell within the human body. Muse cells exist in the blood, bone marrow, and connective tissue of various organs. They have the capacity for triploblastic differentiation; Muse cells can differentiate into various cells within the endoderm (e.g. lungs, liver, pancreas), mesoderm (e.g. heart, kidneys, bones, blood vessels) and ectoderm (e.g. nervous tissue and epidermis). As Muse cells are endogenous to the human body, they have low safety concerns and are characterized by their low tumorigenicity. Due to these characteristics, Muse cells are expected to play an integral role in numerous regenerative therapies for a wide range of diseases.

Muse Cells IMAGE

Provided by Professor Mari Dezawa (Stem Cell Biology and Histology, Tohoku University School of Medicine)

About Regenerative Medicine

Regenerative medicine is a field of medicine that focuses on regaining lost or impaired function using cells or tissues. It is expected that diseases untreatable by conventional methods will now become treatable.

New Treatments by
Regenerative Medicine

Regenerative medical products approved in Japan include the following:

  • ・Autologous Cultured Epidermis
  • ・Autologous Cultured Cartilage
  • ・Autologous Cultured Corneal Epithelium
  • ・Autologous Skeletal Myoblast Sheets
  • ・Human (autologous) bone marrow-derived mesenchymal stem cells
  • ・Human (allogenic) bone marrow-derived mesenchymal stem cells

These are novel treatments in which cells derived from either the patient themselves (autologous) or from a donor (allogenic) are cultured and prepared, then subsequently administered to the patient.

About Regenerative Medicine Using Muse Cells

General Outline of Regenerative Medicine using Muse cells* This video has no sound.

In regenerative therapies using Muse cells, Muse cells collected from a donor are administered to the patient directly via intravenous drip. This method does not require gene transfer or differentiation prior to administration, and there is also no need for surgery to deliver cells. Administered Muse cells recognize SOS signals generated by an injured organ, accumulate to the damaged site, spontaneously differentiate into the cells of the injured tissue. They subsequently engraft there and repair the tissues/organ, and finally, restoring once-impaired function.

Thus, regenerative medicine using Muse cells
can be considered to be closer to “Reparative Medicine”.

Many Excellent Practical Advantages

Regenerative medicine using Muse cells has the following advantages:

  • Gene transfer is not required and safety concerns, including tumorigenic transformation, are very low.
  • Donor matching is not required, since the possibility of rejection is low even with the administration of donor (allogenic) cells.
  • It can be administered immediately, due to not having to induce differentiation prior to administration.
  • It is less invasive due to administration by intravenous drip.

As such, this treatment has the potential to become commonplace for patients.

About Research and development in the Life Science Institute, Inc. (LSII)

LSII aims to realize Reparative Medicine through research and development of Muse cell-based products.

Taking on the Challenge of Ensuring Product Safety

The key for research and development of "regenerative medical products" is the establishment of manufacturing processes and quality control test methods. Especially when making products of living cells, conventional methods of sterilization such as heating are unsuitable. Therefore, it is necessary to precisely manage each step in the production process, from gathering the raw materials and maintaining cell banks to culturing cells and formulating the final product. This will allow for a manufacturing process that can produce Muse cell-based products of a guaranteed quality and quantity. As a final step, the development of test methods to ensure the quality of Muse cell-based products is also needed.

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